Research Article

HIFα Targeted for VHL-Mediated Destruction by Proline Hydroxylation: Implications for O2 Sensing

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Science  20 Apr 2001:
Vol. 292, Issue 5516, pp. 464-468
DOI: 10.1126/science.1059817

Article Information

vol. 292 no. 5516 464-468

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History: 
  • Received for publication February 12, 2001
  • Accepted for publication March 19, 2001

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Author Information

  1. Mircea Ivan1,
  2. Keiichi Kondo1,
  3. Haifeng Yang1,
  4. William Kim1,
  5. Jennifer Valiando1,
  6. Michael Ohh1,
  7. Adrian Salic3,
  8. John M. Asara4,
  9. William S. Lane4,
  10. William G. Kaelin Jr.1,2,*
  1. 1 Dana-Farber Cancer Institute and Brigham and Women's Hospital,
  2. 2 Howard Hughes Medical Institute, Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA.
  3. 3 Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.
  4. 4 Microchemistry and Proteomics Analysis Facility, Harvard University, Cambridge, MA 02138, USA.

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