Research Article

Targeting of HIF-α to the von Hippel-Lindau Ubiquitylation Complex by O2-Regulated Prolyl Hydroxylation

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Science  20 Apr 2001:
Vol. 292, Issue 5516, pp. 468-472
DOI: 10.1126/science.1059796

Article Information

vol. 292 no. 5516 468-472

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Print ISSN: 
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History: 
  • Received for publication February 12, 2001
  • Accepted for publication March 19, 2001

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Author Information

  1. Panu Jaakkola1,*,
  2. David R. Mole1,*,
  3. Ya-Min Tian1,
  4. Michael I. Wilson1,
  5. Janine Gielbert2,
  6. Simon J. Gaskell2,
  7. Alexander von Kriegsheim3,
  8. Holger F. Hebestreit3,
  9. Mridul Mukherji4,
  10. Christopher J. Schofield4,
  11. Patrick H. Maxwell1,,
  12. ‡ Christopher W. Pugh1,,
  13. ‡ Peter J. Ratcliffe1,
  1. 1 The Henry Wellcome Building of Genomic Medicine, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK.
  2. 2 Michael Barber Centre for Mass Spectrometry, Department of Chemistry, University of Manchester Institute of Science and Technology, Manchester M60 1QD, UK.
  3. 3 Glycobiology Institute, University of Oxford, South Parks Road, Oxford OX1 3QU, UK.
  4. 4 The Oxford Centre for Molecular Sciences and The Dyson Perrins Laboratory, University of Oxford, South Parks Road, Oxford OX1 3QY, UK.

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