Report

astray, a Zebrafish roundabout Homolog Required for Retinal Axon Guidance

See allHide authors and affiliations

Science  20 Apr 2001:
Vol. 292, Issue 5516, pp. 507-510
DOI: 10.1126/science.1059496

You are currently viewing the abstract.

View Full Text

Log in to view the full text

Log in through your institution

Log in through your institution

Abstract

As growing retinotectal axons navigate from the eye to the tectum, they sense guidance molecules distributed along the optic pathway. Mutations in the zebrafish astray gene severely disrupt retinal axon guidance, causing anterior-posterior pathfinding defects, excessive midline crossing, and defasciculation of the retinal projection. Eye transplantation experiments show that astrayfunction is required in the eye. We identify astray as zebrafish robo2, a member of the Roundabout family of axon guidance receptors. Retinal ganglion cells express robo2 as they extend axons. Thus, robo2 is required for multiple axon guidance decisions during establishment of the vertebrate visual projection.

  • * To whom correspondence should be addressed at Department of Neurobiology and Anatomy, 401 MREB, University of Utah Medical Center, 50 North Medical Drive, Salt Lake City, UT 84132, USA. E-mail: chi-bin.chien{at}hsc.utah.edu

View Full Text