PerspectiveCell Biology

Telomere Capping--One Strand Fits All

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Science  11 May 2001:
Vol. 292, Issue 5519, pp. 1075-1076
DOI: 10.1126/science.1061032

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How do different organisms protect the ends of their chromosomes (telomeres) from being degraded? Although at first sight it seems that organisms as diverse as ciliates, yeast, and mammalian cells have chosen different modes of telomere protection, it now transpires, as De Lange explains in her Perspective, that they all have one thing in common: a single-stranded DNA binding protein that forms a protective cap over the end of the telomere (Baumann and Cech).