PerspectiveCell Biology

GGAs Tie Up the Loose Ends

Science  01 Jun 2001:
Vol. 292, Issue 5522, pp. 1663-1665
DOI: 10.1126/science.1062239

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Cargo receptors, which recruit cargo proteins into transport vesicles, must themselves be sorted into appropriate vesicles budding from the correct cellular compartment. The job of sorting CI-MPR and CD-MPR cargo receptors into newly forming vesicles at the trans-Golgi network (TGN) has been widely attributed to the adaptor protein AP-1. Now, as Tooze explains in her Perspective, the job of sorting MPRs into TGN vesicles appears to be carried out instead by members of the GGA protein family ( Zhu et al., Puertollano et al.).