Agrin--A Bridge Between the Nervous and Immune Systems

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Science  01 Jun 2001:
Vol. 292, Issue 5522, pp. 1667-1668
DOI: 10.1126/science.1061542

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Agrin--a glycoprotein known to be important in the formation of neuronal synapses, particularly those between motor neurons and muscle cells (neuromuscular junctions)--now has been found on the surface of T lymphocytes ( Khan et al.). In an informative odyssey through the land of neuronal and immunological synapses, Trautmann and Vivier reveal the similarities and differences between neuronal and immune cell agrin and reveal what this molecule does in neuromuscular junctions and in synapses between T cells and antigen-presenting cells.