PerspectiveMolecular Biology

Getting p53 Out of the Nucleus

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Science  08 Jun 2001:
Vol. 292, Issue 5523, pp. 1851-1852
DOI: 10.1126/science.1062238

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Why does the p53 tumor suppressor protein need two nuclear export signals? In their Perspective, Gottifredi and Prives set out to answer this question. They discuss new findings (Zhang and Xiong) suggesting that, in the unstressed cell, the two nuclear export signals may act together to promote the movement of p53 from the nucleus into the cytoplasm, where it is degraded.