DATABASE: Pumped Up

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Science  15 Jun 2001:
Vol. 292, Issue 5524, pp. 1971
DOI: 10.1126/science.292.5524.1971b

A grueling workout, a trip into space, and old age share one thing in common: They can alter the activity pattern of genes in the muscles, as some genes work harder and others slack off. To allow quick access to the scattered data on gene activity in muscles, researchers at Boston University are building Sarcogene, a database of nearly 500 and counting experiments that measured muscle RNA levels under conditions ranging from spaceflight to cycling. Search the database by terms such as gene, type of activity, or muscle, and you'll get a brief report that includes raw data on RNA levels and PubMed links. Sarcogene's curators also plan to add data from DNA microarrays.

muscle.bu.edu/Home/home.htm

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