News of the WeekNEURODEGENERATIVE DISEASE

Using the Fruit Fly to Model Tau Malfunction

+ See all authors and affiliations

Science  15 Jun 2001:
Vol. 292, Issue 5524, pp. 1983-1984
DOI: 10.1126/science.292.5524.1983a

You are currently viewing the summary.

View Full Text

Via your Institution

Log in through your institution

Log in through your institution


Summary

In work published online by Science on 14 June (www.sciencexpress.org), researchers show that fruit flies producing the human tau protein--which forms part of abnormal intracellular structures called tangles seen in the brains of patients with Alzheimer's disease and certain other dementias--undergo brain neuron degeneration. But in a surprising finding, the dying fly neurons do not contain tangles. Some researchers suggest that the results indicate that defective tau proteins can kill neurons without forming tangles; others caution, however, that the lack of tangles might mean that flies aren't a good model of human dementias.

Related Content