How to Make a Superior Cell

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Science  15 Jun 2001:
Vol. 292, Issue 5524, pp. 2024-2025
DOI: 10.1126/science.1062556

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Engineering cells and microbes to make a commercially valuable product has been successfully accomplished by introducing foreign genes into target cells ( Zaslavskaia et al.). According to the Perspective by Stephanopoulos and Kelleher, successful gene modification may require intervention at multiple steps in a metabolic pathway to optimize the desired cellular properties. As the authors explain, this necessitates successive rounds of genetic modification and physiological evaluation, a strategy that forms the basis of metabolic engineering.