Modulation of Cell Proliferation by Heterotrimeric G Protein in Arabidopsis

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Science  15 Jun 2001:
Vol. 292, Issue 5524, pp. 2066-2069
DOI: 10.1126/science.1059040

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The α subunit of a prototypical heterotrimeric GTP-binding protein (G protein), which is encoded by a single gene (GPA1) in Arabidopsis, is a modulator of plant cell proliferation. gpa1 null mutants have reduced cell division in aerial tissues throughout development. Inducible overexpression of GPA1 in Arabidopsis confers inducible ectopic cell division. GPA1 overexpression in synchronized BY-2 cells causes premature advance of the nuclear cycle and the premature appearance of a division wall. Results from loss of function and ectopic expression and activation of GPA1indicate that this subunit is a positive modulator of cell division in plants.

  • * Present address: Biology Department, MS-9160, Western Washington University, Bellingham, WA 98225, USA.

  • To whom correspondence should be addressed at Department of Biology, CB#3280, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599–3280, USA. E-mail: alan_jones{at}

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