Report

Vitamin C-Induced Decomposition of Lipid Hydroperoxides to Endogenous Genotoxins

Science  15 Jun 2001:
Vol. 292, Issue 5524, pp. 2083-2086
DOI: 10.1126/science.1059501

You are currently viewing the abstract.

View Full Text

Via your Institution

Log in through your institution

Log in through your institution


Abstract

Epidemiological data suggest that dietary antioxidants play a protective role against cancer. This has led to the proposal that dietary supplementation with antioxidants such as vitamin C (vit C) may be useful in disease prevention. However, vit C has proved to be ineffective in cancer chemoprevention studies. In addition, concerns have been raised over potentially deleterious transition metal ion–mediated pro-oxidant effects. We have now determined that vit C induces lipid hydroperoxide decomposition to the DNA-reactive bifunctional electrophiles 4-oxo-2-nonenal, 4,5-epoxy-2(E)-decenal, and 4-hydroxy-2-nonenal. The compound 4,5-Epoxy-2(E)-decenal is a precursor of etheno-2′-deoxyadenosine, a highly mutagenic lesion found in human DNA. Vitamin C–mediated formation of genotoxins from lipid hydroperoxides in the absence of transition metal ions could help explain its lack of efficacy as a cancer chemoprevention agent.

  • * To whom correspondence should be addressed. E-mail: ian{at}spirit.gcrc.upenn.edu

View Full Text

Related Content