News of the WeekCELL CYCLE RESEARCH

DNA: Once Copied, Thrice Blocked

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Science  29 Jun 2001:
Vol. 292, Issue 5526, pp. 2415-2417
DOI: 10.1126/science.292.5526.2415

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Summary

Although more than a decade ago cell biologists identified the master protein that guarantees that DNA replication occurs only once, they don't understand how it exerts its power. Now, part of that puzzle has been solved. In the 28 June issue of Nature, a team reports that three separate pathways, all under the control of the master coordinator, a protein kinase known as Clb-Cdc28, must work together to prevent a second round of DNA synthesis from getting under way before the cell divides.