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Conditional Restoration of Hippocampal Synaptic Potentiation in GluR-A-Deficient Mice

Science  29 Jun 2001:
Vol. 292, Issue 5526, pp. 2501-2504
DOI: 10.1126/science.1059365

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Abstract

Plasticity of mature hippocampal CA1 synapses is dependent onl-α-amino-3-hydroxy-5-methylisoxazole-4-propionate (AMPA) receptors containing the glutamate receptor A (GluR-A) subunit. In GluR-A–deficient mice, plasticity could be restored by controlled expression of green fluorescent protein (GFP)–tagged GluR-A, which contributes to channel formation and displayed the developmental redistribution of AMPA receptors in CA1 pyramidal neurons. Long-term potentiation (LTP) induced by pairing or tetanic stimulation was rescued in adult GluR-A–/– mice when GFPGluR-A expression was constitutive or induced in already fully developed pyramidal cells. This shows that GluR-A–independent forms of synaptic plasticity can mediate the establishment of mature hippocampal circuits that are prebuilt to express GluR-A–dependent LTP.

  • * Present address: Department of Neurophysiology, Faculty of Biology, Vrije University, 1081 HV, Amsterdam, Netherlands.

  • To whom correspondence should be addressed. E-mail: sprengel{at}mpimf-heidelberg.mpg.de

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