PerspectiveDevelopment

The Message Is in the Translation

Science  06 Jul 2001:
Vol. 293, Issue 5527, pp. 60-62
DOI: 10.1126/science.1062237

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Summary

It has been well established that cells control the activities of proteins by regulating their degradation. Now it seems cells also control protein activity by regulating when and where mRNAs encoding cellular proteins are translated. In their Perspective, Richter and Theurkauf examine how regulation of the translation of cyclin B and hunchback mRNAs controls cell proliferation and pattern formation in the developing fly embryo.