News of the WeekVirology

New Finding Heats Up the Hot Zone

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Science  13 Jul 2001:
Vol. 293, Issue 5528, pp. 191
DOI: 10.1126/science.293.5528.191a

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Researchers have uncovered an intriguing lead in determining the modus operandi of Ebola and its equally gruesome cousin, Marburg: a molecule that helps both viruses infect cells. As they describe in the 13 July issue of Cell, these viruses have an intimate relationship with folate receptor-a (FR-a), which is found on the surface of many cell types. If FR-a does turn out to be an important accomplice for viral entry, this insight might point the way to novel treatment and vaccine strategies.