How DNA Shuffling Works

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Science  13 Jul 2001:
Vol. 293, Issue 5528, pp. 237
DOI: 10.1126/science.293.5528.237

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The core technology behind directed molecular evolution is the polymerase chain reaction, the "molecular photocopier" that's used to amplify small amounts of DNA. But scientists at one biotech that is using the technique to produce vaccines have given it a special tweak to produce what they call "DNA shuffling."