Protecting Against Bad Air

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Science  20 Jul 2001:
Vol. 293, Issue 5529, pp. 442-443
DOI: 10.1126/science.1063292

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It has been suspected that G6PD deficiency is widespread among humans because it confers a selective advantage. In a Perspective, Luzzatto and Notaro discuss findings from a molecular analysis of G6PD gene variants ( Tishkoff et al.), which support the notion that G6PD deficiency has been selected for because it protects against infection with Plasmodium falciparum, the parasite that causes a fatal form of malaria.