Huntingtin--Profit and Loss

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Science  20 Jul 2001:
Vol. 293, Issue 5529, pp. 445-446
DOI: 10.1126/science.1063429

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Huntington's disease (HD) is a neurodegenerative disease caused by an expanded run of glutamine repeats in the huntingtin protein. How this glutamine expansion results in the selective loss of striatal neurons characteristic of HD is not known. In a Perspective, Trottier and Mandel discuss new findings demonstrating that loss of the beneficial effects of the wild-type huntingtin protein, including production of BDNF, results in the demise of striatal neurons, which depend on BDNF for their survival.