Reliability of Protocol Reviews for Animal Research

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Science  27 Jul 2001:
Vol. 293, Issue 5530, pp. 608-609
DOI: 10.1126/science.1061621

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A random sample of 50 Institutional Animal Care and Use Committees (IACUCs) participated in a study of the protocol review process. Each committee submitted three animal behavior protocols it had recently reviewed, and these protocols were reviewed a second time by another participating committee. The results reported in this Policy Forum showed low levels of reliability in protocol judgments within and between committees. In addition, a majority of approved research protocols were disapproved or deferred by the second committee.