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Lysophosphatidylcholine as a Ligand for the Immunoregulatory Receptor G2A

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Science  27 Jul 2001:
Vol. 293, Issue 5530, pp. 702-705
DOI: 10.1126/science.1061781

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Abstract

Although the biological actions of the cell membrane and serum lipid lysophosphatidylcholine (LPC) in atherosclerosis and systemic autoimmune disease are well recognized, LPC has not been linked to a specific cell-surface receptor. We show that LPC is a high-affinity ligand for G2A, a lymphocyte-expressed G protein–coupled receptor whose genetic ablation results in the development of autoimmunity. Activation of G2A by LPC increased intracellular calcium concentration, induced receptor internalization, activated ERK mitogen-activated protein kinase, and modified migratory responses of Jurkat T lymphocytes. This finding implicates a role for LPC-G2A interaction in the etiology of inflammatory autoimmune disease and atherosclerosis.

  • * These authors contributed equally to this work.

  • To whom correspondence should be addressed. E-mail: owenw{at}microbio.ucla.edu (O.N.W.); xuy{at}ccf.org(Y.X.)

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