PerspectivePROTEIN SYNTHESIS

The Perks of Balancing Glucose

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Science  03 Aug 2001:
Vol. 293, Issue 5531, pp. 818-819
DOI: 10.1126/science.1062937

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Summary

What do the regulation of translation initiation and glucose metabolism have to do with each other? Quite a lot, it seems, according to Sonenberg and Newgard in their Perspective. They discuss new findings that identify the kinase responsible for inactivating eIF2--a factor that is required for translation initiation (and hence protein synthesis)--when the endoplasmic reticulum is under stress. Loss of this kinase results in destruction of insulin-producing b cells in the pancreas and dysregulation of glucose homeostasis.