Report

Sorting of Striatal and Cortical Interneurons Regulated by Semaphorin-Neuropilin Interactions

Science  03 Aug 2001:
Vol. 293, Issue 5531, pp. 872-875
DOI: 10.1126/science.1061891

You are currently viewing the abstract.

View Full Text

Via your Institution

Log in through your institution

Log in through your institution


Abstract

Most striatal and cortical interneurons arise from the basal telencephalon, later segregating to their respective targets. Here, we show that migrating cortical interneurons avoid entering the striatum because of a chemorepulsive signal composed at least in part of semaphorin 3A and semaphorin 3F. Migrating interneurons expressing neuropilins, receptors for semaphorins, are directed to the cortex; those lacking them go to the striatum. Loss of neuropilin function increases the number of interneurons that migrate into the striatum. These observations reveal a mechanism by which neuropilins mediate sorting of distinct neuronal populations into different brain structures, and provide evidence that, in addition to guiding axons, these receptors also control neuronal migration in the central nervous system.

  • * To whom correspondence should be addressed. E-mail: jlrr{at}cgl.ucsf.edu

View Full Text

Related Content