PerspectiveGENE REGULATION

A Paradigm for Precision

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Science  10 Aug 2001:
Vol. 293, Issue 5532, pp. 1054-1055
DOI: 10.1126/science.1064050

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Summary

Regulating the expression of target genes in response to different conditions is one of the most daunting tasks facing the cell. In a Perspective, Struhl describes the intricate steps involved in assembly of a precise transcriptional on-off switch called the enhanceosome, which regulates the transcription of the interferon-b gene in response to viral infection ( Munshi et al.).