RNA Rules--At Least Sometimes

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Science  10 Aug 2001:
Vol. 293, Issue 5532, pp. 1066
DOI: 10.1126/science.293.5532.1066

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A great deal of recent evidence has shown that proteins, especially enzymes that modify either DNA itself or the histone proteins that package it into chromatin, can alter gene activity, sometimes permanently (see main text). But proteins aren't alone in producing such epigenetic effects. A variety of RNAs can interfere with gene expression at multiple points along the road from DNA to protein.