PerspectiveCell Biology

A Switch to Release the Motor

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Science  17 Aug 2001:
Vol. 293, Issue 5533, pp. 1263-1264
DOI: 10.1126/science.1064602

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Most organelle transport ceases when cells begin mitosis. But how is this accomplished? As Cheney and Rodriguez explain in their Perspective, cell cycle-dependent phosphorylation of myosin-V--a motor protein that moves organelles along actin filaments--results in release of myosin-V from the organelle and cessation of actin-based organelle transport ( Karcher et al.).