Report

Immunocyte Ca2+ Influx System Mediated by LTRPC2

Science  17 Aug 2001:
Vol. 293, Issue 5533, pp. 1327-1330
DOI: 10.1126/science.1062473

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Abstract

We characterized an activation mechanism of the human LTRPC2 protein, a member of the transient receptor potential family of ion channels, and demonstrated that LTRPC2 mediates Ca2+ influx into immunocytes. Intracellular pyrimidine nucleotides, adenosine 5′-diphosphoribose (ADPR), and nicotinamide adenine dinucleotide (NAD), directly activated LTRPC2, which functioned as a Ca2+-permeable nonselective cation channel and enabled Ca2+ influx into cells. This activation was suppressed by intracellular adenosine triphosphate. These results reveal that ADPR and NAD act as intracellular messengers and may have an important role in Ca2+ influx by activating LTRPC2 in immunocytes.

  • * These authors contributed equally to this work.

  • To whom correspondence should be addressed. E-mail: sano.yorikata{at}yamanouchi.co.jp

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