Tauists and βaptists United--Well Almost!

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Science  24 Aug 2001:
Vol. 293, Issue 5534, pp. 1446-1447
DOI: 10.1126/science.1064684

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Controversy still rages over which of the two hallmark pathologies of Alzheimer's disease (AD), amyloid plaques and tau tangles, is the primary cause of neurodegeneration in the brain. As many suspected and as Lee points out in her Perspective, the two pathologies are not separate processes. New work ( Lewis et al., Götz et al.) in transgenic mice shows that amyloid-b deposits influence the formation of tau tangles in areas of the brain known to be affected in AD.