PerspectiveCell Biology

Caveolae--Not Just Craters in the Cellular Landscape

See allHide authors and affiliations

Science  24 Aug 2001:
Vol. 293, Issue 5534, pp. 1447-1448
DOI: 10.1126/science.1061079

You are currently viewing the summary.

View Full Text

Log in to view the full text

Log in through your institution

Log in through your institution


Caveolae are small invaginations in the plasma membrane of mammalian cells that seem to be important for signal transduction and uptake of macromolecules. According to Shin and Abraham in their Perspective, recent work reveals that these cellular craters have been commandeered by pathogens and bacterial toxins, enabling them to gain entry to host cells while avoiding the perils of classic endocytosis and the lysosomal degradation pathway.