Clotting Factors Build Blood Vessels

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Science  31 Aug 2001:
Vol. 293, Issue 5535, pp. 1602-1604
DOI: 10.1126/science.1064981

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Recent research suggests that the blood clotting cascade and events during formation of new blood vessels (angiogenesis) are not disconnected processes. In a Perspective, Carmeliet discusses new findings in mouse embryos lacking the thrombin receptor PAR1 that support an intimate connection between blood clotting and angiogenesis ( Griffin et al.).