PerspectiveMolecular Biology

Turning Gene Regulation on Its Head

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Science  14 Sep 2001:
Vol. 293, Issue 5537, pp. 2018-2019
DOI: 10.1126/science.1064982

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Regulation of the trp operon in E. coli (which contains genes encoding enzymes that make the amino acid tryptophan) has been well worked out. The expression of the trp operon in other bacteria, such as B. subtilis, is less well understood. In a Perspective, Losick and Sonenshein describe new work (Valbuzzi and Yanofsky) that reveals the workings of the B. subtilis trp operon and the unique way in which this organism fine-tunes gene expression.