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BAFF-R, a Newly Identified TNF Receptor That Specifically Interacts with BAFF

Science  14 Sep 2001:
Vol. 293, Issue 5537, pp. 2108-2111
DOI: 10.1126/science.1061965

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Abstract

B cell homeostasis has been shown to critically depend on BAFF, the B cell activation factor from the tumor necrosis factor (TNF) family. Although BAFF is already known to bind two receptors, BCMA and TACI, we have identified a third receptor for BAFF that we have termed BAFF-R. BAFF-R binding appears to be highly specific for BAFF, suggesting a unique role for this ligand-receptor interaction. Consistent with this, the BAFF-R locus is disrupted in A/WySnJ mice, which display a B cell phenotype qualitatively similar to that of the BAFF-deficient mice. Thus, BAFF-R appears to be the principal receptor for BAFF-mediated mature B cell survival.

  • * Present address: Department of Biologics Research, Merck & Co., 126 East Lincoln Avenue, RY 80Y-310, Rahway, NJ 07065, USA.

  • To whom correspondence should be addressed. E-mail: christine_ambrose{at}biogen.com

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