News of the WeekGenome Research

Possible New Heart Disease Risk Factor

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Science  05 Oct 2001:
Vol. 294, Issue 5540, pp. 33
DOI: 10.1126/science.294.5540.33a

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After embarking on a basic study of gene regulation, a research team has instead uncovered a new gene that may be an important risk factor in cardiovascular diseases. The new gene, reported on page 169, encodes a previously unknown member of the apolipoprotein family of proteins, which influence blood lipid levels. The researchers have also shown that mutations in the gene lead to increased blood triglyceride levels in both mice and humans.