PerspectiveCELL CYCLE

Order from Destruction

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Science  05 Oct 2001:
Vol. 294, Issue 5540, pp. 66-67
DOI: 10.1126/science.1066237

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Cyclin E and its kinase partner CDK2 are essential for initiating duplication of the genome during S phase of the cell cycle. But how is cyclin E itself regulated? In a comprehensive Perspective, Bartek and Lukas describe new findings in this issue ( Koepp et al. ) and elsewhere that identify an F-box protein called Fbw7/hCdc4/Ago as the controller of cyclin E degradation. Intriguingly, mutations in this F-box protein are associated with some forms of breast and ovarian cancer.