PerspectiveSignal Transduction

Calcium Channels--Link Locally, Act Globally

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Science  12 Oct 2001:
Vol. 294, Issue 5541, pp. 318-319
DOI: 10.1126/science.1066160

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Ca-dependent gene transcription and L-type Cachannel inactivation share a common initiating event. As Ikeda explains in his Perspective, in each case, local increases in [Ca] result in binding to calmodulin that is tethered to the Cachannel protein. An accompanying conformational change triggers phosphorylation of the transcription factor CREB and closure, or inactivation, of L-type Cachannels ( Dolmetsch et al.).