Endothelium--Chicken Soup for the Endoderm

Science  19 Oct 2001:
Vol. 294, Issue 5542, pp. 530-531
DOI: 10.1126/science.1066282

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Endothelial cells in blood vessels are known to be important during the later stages of organ development in the embryo. However, their involvement at the induction stage of organ formation has not been previously documented. As Bahary and Zon explain in their Perspective, new work demonstrates that endothelial cells secrete factors early in development that induce embryonic endoderm to become liver or pancreas ( Matsumoto et al., Lammert et al.).