Report

Regulation of Cutaneous Malignancy by γδ T Cells

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Science  19 Oct 2001:
Vol. 294, Issue 5542, pp. 605-609
DOI: 10.1126/science.1063916

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Abstract

The localization of γδ T cells within epithelia suggests that these cells may contribute to the down-regulation of epithelial malignancies. We report that mice lacking γδ cells are highly susceptible to multiple regimens of cutaneous carcinogenesis. After exposure to carcinogens, skin cells expressed Rae-1 and H60, major histocompatibility complex–related molecules structurally resembling human MICA. Each of these is a ligand for NKG2d, a receptor expressed by cytolytic T cells and natural killer (NK) cells. In vitro, skin-associated NKG2d+ γδ cells killed skin carcinoma cells by a mechanism that was sensitive to blocking NKG2d engagement. Thus, local T cells may use evolutionarily conserved proteins to negatively regulate malignancy.

  • * These authors contributed equally to this report.

  • To whom correspondence should be addressed. E-mail: adrian.hayday{at}kcl.ac.uk

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