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A Trypanosome Structure Involved in Transmitting Cytoplasmic Information During Cell Division

Science  19 Oct 2001:
Vol. 294, Issue 5542, pp. 610-612
DOI: 10.1126/science.1063775

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Abstract

African trypanosomes are protozoan parasites that cause sleeping sickness in humans through a tsetse fly vector. The procyclic form ofTrypanosoma brucei has a single, attached flagellum that describes a helical path along the cell from posterior to anterior. During division, a specific flagellum-flagellum connection is elaborated between the new and old flagellum. This connector was present only during cell duplication and was found to be involved in the replication of the helical cell pattern and polarity. This finding implicates the concept of cytotaxis in cell morphogenesis in trypanosomes.

  • * Present address: Discipline of Ophthalmology, Faculty of Medicine and Health Sciences, University of Auckland, Auckland, New Zealand.

  • Present address: Muséum National d'Histoire Naturelle, Laboratoire de Biophysique, 43 rue Cuvier, 75231 Paris Cedex 05, France.

  • To whom correspondence should be addressed. E-mail: k.gull{at}man.ac.uk

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