Report

An Abundant Class of Tiny RNAs with Probable Regulatory Roles in Caenorhabditis elegans

Science  26 Oct 2001:
Vol. 294, Issue 5543, pp. 858-862
DOI: 10.1126/science.1065062

You are currently viewing the abstract.

View Full Text

Via your Institution

Log in through your institution

Log in through your institution


Abstract

Two small temporal RNAs (stRNAs), lin-4 andlet-7, control developmental timing in Caenorhabditis elegans. We find that these two regulatory RNAs are members of a large class of 21- to 24-nucleotide noncoding RNAs, called microRNAs (miRNAs). We report on 55 previously unknown miRNAs in C. elegans. The miRNAs have diverse expression patterns during development: a let-7 paralog is temporally coexpressed withlet-7; miRNAs encoded in a single genomic cluster are coexpressed during embryogenesis; and still other miRNAs are expressed constitutively throughout development. Potential orthologs of several of these miRNA genes were identified in Drosophila and human genomes. The abundance of these tiny RNAs, their expression patterns, and their evolutionary conservation imply that, as a class, miRNAs have broad regulatory functions in animals.

  • * To whom correspondence should be addressed. E-mail: dbartel{at}wi.mit.edu

View Full Text

Related Content