Neurocreationism--Making New Cortical Maps

Science  02 Nov 2001:
Vol. 294, Issue 5544, pp. 1011-1012
DOI: 10.1126/science.294.5544.1011

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In developing mammals, how does the cerebral cortex become compartmentalized into different regions responsible for functions as diverse as motor control and sensory perception? Rakic explains in his Perspective that morphogenetic molecules such as FGF8 (Fukuchi-Shimogori and Grove) form gradients that specify the boundaries of different cortical regions, which are then further modified by input from the thalamus and other cerebral structures.