Fat Hormone Makes a Comeback

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Science  02 Nov 2001:
Vol. 294, Issue 5544, pp. 979
DOI: 10.1126/science.294.5544.979b

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A study of 13 people with defects in one copy of their leptin gene has renewed researchers' hopes for leptin's potential as a pound-shedding drug. The people are heavier and packed with a significantly higher percentage of body fat than family members with two normal copies of the leptin gene. The study suggests that at least in some people, low leptin levels--a treatable condition--can lead to obesity.