Antigen Presentation--Losing Its Shine in the Absence of GILT

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Science  09 Nov 2001:
Vol. 294, Issue 5545, pp. 1294-1295
DOI: 10.1126/science.1066725

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T cell activation requires presentation of antigen by antigen-presenting cells (APCs). Before the antigen can be presented on the APC surface, it must be processed within the endosomes and lysosomes of APCs into short peptides, which are then assembled into complexes with MHC class II molecules. In a Perspective, Watts identifies the enzyme GILT as a necessary component for efficient processing of antigen containing disulfide bonds ( Maric et al.).