DATABASE: Phosphorylation Station

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Science  23 Nov 2001:
Vol. 294, Issue 5547, pp. 1623
DOI: 10.1126/science.294.5547.1623b

Cells can activate or hamstring their proteins by sticking on phosphate groups, which change the protein's shape. The reaction, called protein phosphorylation, “is probably one of the most important regulatory mechanisms in cells,” says biochemist Peter Kennelly of Virginia Tech in Blacksburg. Drawing from more than 20 years' worth of publications, this brand-new Web site from Kennelly and colleagues provides a wealth of data on the phosphorylated proteins of bacteria and archaea. The database specifies the functional effects of phosphorylation (if known) and the amino acids involved, as well as offering the original reference and links to PubMed and the usual gene and protein databases.

vigen.biochem.vt.edu/xpd/xpd.htm

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