News FocusGene Therapy

Safer and Virus-Free?

Science  23 Nov 2001:
Vol. 294, Issue 5547, pp. 1638-1642
DOI: 10.1126/science.294.5547.1638

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Most nonviral vectors for gene therapy fly under the radar of the immune system, and they're cheaper and easier to manufacture than viral vectors. But most of them have not been as efficient as viruses in shuttling genes into cells, and the genes that were delivered didn't remain active for long. In the past few years, though, that has begun to change.