PerspectiveSTRUCTURE

Action at the Y-branch

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Science  23 Nov 2001:
Vol. 294, Issue 5547, pp. 1660-1661
DOI: 10.1126/science.1067619

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Summary

Cell motility depends on reorganization of the actin filament network just beneath the plasma membrane. In a Perspective, Weeds and Yeoh discuss the high-resolution structure of the Arp2/3 complex, which directs the formation of daughter actin filaments that branch off from parent filaments ( Robinson et al.). They reveal what the structure tells us about how Arp2/3 directs this actin filament branching.