PerspectiveCell Biology

Encounters in Space

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Science  23 Nov 2001:
Vol. 294, Issue 5547, pp. 1661-1663
DOI: 10.1126/science.1066919

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Cultured cells are known to form focal and fibrillar adhesions with the substrate on which they grow. But to what extent these adhesions represent those formed in vivo is a matter of debate. In a Perspective, Geiger discusses new findings ( Cukierman et al.) claiming that the formation of physiological adhesions depends on the correct combination of molecular composition, topography, and pliability of the matrix.