PerspectiveSignal Transduction

A New Thread in an Intricate Web

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Science  30 Nov 2001:
Vol. 294, Issue 5548, pp. 1845-1847
DOI: 10.1126/science.1067418

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Understanding how biochemical pathways are connected in the cell is one of the big challenges facing cell biologists. In a Perspective, von Zastrow and Mostov describe new work that identifies a protein called RGS-PX1 as the linchpin that connects signal transduction activated by G protein-coupled receptors with membrane trafficking events.