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Hedgehog Signaling: A Tale of Two Lipids

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Science  30 Nov 2001:
Vol. 294, Issue 5548, pp. 1879-1881
DOI: 10.1126/science.1064115

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Hedgehog proteins constitute one of the major classes of intercellular signals that control inductive interactions during animal development. These proteins undergo unusual lipid modifications and signal through an unconventional transmembrane protein receptor that is characterized by a sequence motif implicated in sterol sensing. Recent studies suggest that the lipid adducts regulate the range and potency of the signals, whereas the sterol-sensing domain is essential for receptor activity.

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