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Physiological Migration of Hematopoietic Stem and Progenitor Cells

Science  30 Nov 2001:
Vol. 294, Issue 5548, pp. 1933-1936
DOI: 10.1126/science.1064081

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Abstract

Hematopoietic stem cells (HSCs) reside predominantly in bone marrow, but low numbers of HSCs are also found in peripheral blood. We examined the fate of blood-borne HSCs using genetically marked parabiotic mice, which are surgically conjoined and share a common circulation. Parabionts rapidly established stable, functional cross engraftment of partner-derived HSCs and maintained partner-derived hematopoiesis after surgical separation. Determination of the residence time of injected blood-borne progenitor cells suggests that circulating HSCs/progenitors are cleared quickly from the blood. These data demonstrate that HSCs rapidly and constitutively migrate through the blood and play a physiological role in, at least, the functional reengraftment of unconditioned bone marrow.

  • * These authors contributed equally to this work.

  • To whom correspondence should be addressed. E-mail: irv{at}stanford.edu

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