Bigger Is Not Better

See allHide authors and affiliations

Science  07 Dec 2001:
Vol. 294, Issue 5549, pp. 2049
DOI: 10.1126/science.294.5549.2049k

The tumor suppressor gene Pten also plays a critical role for normal brain development. Standard Pten deletion mutants in mice are lethal in early development, so Groszer et al. (p. 2186; see the Perspective by Penniger and Woodgett) developed a conditional knockout that deletes PTEN in the central nervous system at mid-gestation. These mice showed hyperactivation of certain signal transduction pathways; they also exhibited enlarged brains with multiple malformations, and more and bigger neural cells. Analysis of cell proliferation and apoptosis in the mutant brains suggests that PTEN controls progression of neural progenitor cells through the cell cycle.

Navigate This Article